Chief of Staff – BiomeSense

Location: Chicago, IL (in-person)

Compensation: $125K – $175K salary + 0.3% - 0.5% equity + benefits

About BiomeSense

BiomeSense is a gut microbiome company building a breakthrough sample-to-answer intelligence platform to accelerate the development of novel microbiome-based precision medicine. Our proprietary platform integrates GutLab Technology (continuous, standardized, low-cost microbiome tracking) with MetaBiome AI/ML (bioinformatics purpose-built for large-scale microbiome analysis). Together, these form the first massively scalable data/AI infrastructure for the gut microbiome, unlocking biomarker discovery and product development across oncology, nutrition, drug response, and autoimmune disease.

We partner with leading institutions and researchers including UCSF, UCSD, NIH, and the University of Chicago, and are backed by investors such as Labcorp Ventures, Bluestein Ventures, Seerave Foundation, and Emil Capital Partners.

Role Summary

The Chief of Staff will serve as a strategic partner to the CEO, driving alignment, execution, and scale during a critical growth stage. This role is not about administrative support – it is about being a strategic operator and problem-solver who ensures the company executes with speed and precision.

Your main role will be to act as a force multiplier for the CEO: translating company priorities into action, bridging communication across teams, managing investor and partner processes, and leading special projects that shape the company’s trajectory.

This is a rare opportunity to join a high-growth, venture-backed biotech startup at the inflection point of scaling. It is ideally suited for someone with a consulting, venture capital, or investment banking background who thrives under ambiguity, loves solving complex problems, and wants to accelerate their career in biotech/healthtech leadership.

The role is full-time with in-person attendance at our Chicago office.

Key Responsibilities

Strategic Alignment & Execution: Ensure leadership focus on top priorities (data growth, biomarker targets, revenue milestones) and track execution against goals
Fundraising & Investor Relations: Manage CRM, prepare diligence materials, coordinate investor communications, and drive proactive follow-up
Cross-Functional Coordination: Bridge engineering, bioinformatics, and business development to remove bottlenecks and accelerate deliverables
Board & Partner Engagement: Support logistics and prep for board meetings, advisor sessions, and major partnership discussions
Strategic Projects: Lead CEO-delegated initiatives such as competitive intelligence, partnership diligence, and grant opportunity management
Risk Management: Serve as an 'early-warning system' for execution risks, misalignment, or resource constraints

Qualifications

Required:

3–6 years of relevant experience (consulting, venture capital, investment banking, or startup operations)
Proven ability to structure and drive complex projects in ambiguous, high-pressure environments
Exceptional communication skills – written, verbal, and executive presentation
Strong analytical and problem-solving abilities; comfort working with data and financial models
High discretion, professionalism, and trustworthiness with sensitive information

Preferred:

MBA or advanced degree
Experience in biotech, healthtech, or data-driven life sciences
Prior early-stage startup experience

Skills & Attributes

Structured, pragmatic thinker who can impose order without unnecessary bureaucracy
Ambitious but low-ego – thrives in a role focused on leverage and execution, not spotlight
Comfortable context-switching between investors, scientists, and operators
Fast learner with intellectual range and adaptability
Action-oriented, with a focus on solving problems rather than just flagging them
Able to work independently or as part of a team

Compensation & Benefits

Salary: $125K–$175K, depending on experience
Equity: 0.3%–0.5% stock options
Standard benefits including health coverage, PTO, and parental leave

This role is designed for someone who wants to work hard, learn fast, and make a measurable impact at the intersection of biotech, AI, and precision medicine. If you want a front-row seat to scaling a startup and are excited to help build the future of microbiome-based healthcare, we’d love to hear from you.

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