Description Clinical Trial Manager (CTM) - US/Remote
Job ResponsibilitiesCLINICAL TRIAL MANAGER (CTM) - US/ Remote Lead Global Clinical Trials | Drive Innovation | Advance Patient ImpactAt Syneos Health, we bring together clinical development and commercialization expertise to help our customers accelerate the delivery of life-changing therapies. By integrating clinical operations, medical affairs, and commercial insights, we create smarter, faster development pathways-always with patients at the center.
We're expanding our Clinical Operations team and are seeking Clinical Trial Managers (CTMs) who are passionate about operational excellence, collaborative leadership, and delivering high-quality global clinical trials.
THE ROLE:As a
Clinical Trial Manager, you will serve as the operational leader for one or more clinical trials, owning execution from study start-up through closeout. You'll work within a dynamic, matrixed environment-partnering closely with cross-functional teams, sponsors, and sites to ensure timely, compliant, and high-quality trial delivery.
This is an opportunity to lead complex studies, influence outcomes, and play a key role in advancing innovative therapies to patients worldwide.
WHAT YOU WILL DO:- Lead end-to-end clinical trial execution, ensuring delivery against timelines, quality standards, and budget
- Provide operational oversight of site management and monitoring activities, including on-site and centralized monitoring
- Identify, assess, and proactively mitigate clinical and operational risks using a risk-based management approach (RACT)
- Serve as the primary escalation point for CRAs, investigative sites, and cross-functional stakeholders
- Partner closely with Study Start-Up, Data Management, Biostatistics, Safety, and Patient Recruitment teams to drive milestone achievement
- Leverage integrated systems and data (CTMS, EDC, ePRO, TMF, dashboards) to monitor performance, trends, and risk indicators
- Ensure ongoing inspection readiness and compliance with ICH-GCP, SOPs, and global regulatory requirements
- Lead study-specific training and foster alignment across the clinical trial team
- Review metrics and operational data to anticipate challenges and implement timely solutions
- Mentor and support CRAs, contributing to a culture of accountability, continuous improvement, and collaboration
WHO YOU ARE:Required- Hands-on Clinical Research Associate (CRA) experience, including on-site monitoring (not remote-only)
- 2+ years of experience as a Clinical Trial Manager, preferably within a CRO environment
- Strong understanding of global clinical trial operations and site management
Preferred Strengths- Demonstrated success leading cross-functional, global clinical teams
- Solid experience with risk-based monitoring and centralized oversight models
- Deep knowledge of ICH-GCP and international regulatory requirements
- Strong analytical, critical-thinking, and problem-solving capabilities
- Confident communicator with the ability to navigate complex stakeholder and sponsor environments
- Comfortable working in a global, matrixed organization
- Proficiency with clinical trial systems (CTMS, EDC, ePRO, TMF)
- Experience in oncology and/or ophthalmology is a strong asset
WHY SYNEOS HEALTH?- Be part of a global, innovative organization with a strong and diverse pipeline of clinical programs
- Lead high-impact, complex trials across multiple therapeutic areas
- Work in a collaborative, inclusive environment where your expertise and perspective matter
- Gain exposure to a wide range of sponsors-from emerging biotech to top global pharmaceutical companies
- Access clear pathways for career growth, leadership development, and continuous learning
Salary Range $132,000 - $178,000 USD
At Syneos Health, we believe in providing an environment and culture in which Our People can thrive, develop and advance. We reward and recognize our people by providing valuable benefits and a quality-of-life balance. The benefits for this position may include a company car or car allowance, Health benefits to include Medical, Dental and Vision, Company match 401k, eligibility to participate in Employee Stock Purchase Plan, Eligibility to earn commissions/bonus based on company and individual performance, and flexible paid time off (PTO) and sick time. Because certain states and municipalities have regulated paid sick time requirements, eligibility for paid sick time may vary depending on where you work. Syneos complies with all applicable federal, state, and municipal paid sick time requirements.
Salary Range:
The base salary range represents the anticipated low and high of the Syneos Health range for this position. Actual salary will vary based on various factors such as the candidate's qualifications, skills, competencies, and proficiency for the role.
Get to know Syneos HealthOver the past 5 years, we have worked with 94% of all Novel FDA Approved Drugs, 95% of EMA Authorized Products and over 200 Studies across 73,000 Sites and 675,000+ Trial patients.
No matter what your role is, you'll take the initiative and challenge the status quo with us in a highly competitive and ever-changing environment. Learn more about Syneos Health.
http://www.syneoshealth.com
Additional InformationTasks, duties, and responsibilities as listed in this job description are not exhaustive. The Company, at its sole discretion and with no prior notice, may assign other tasks, duties, and job responsibilities. Equivalent experience, skills, and/or education will also be considered so qualifications of incumbents may differ from those listed in the Job Description. The Company, at its sole discretion, will determine what constitutes as equivalent to the qualifications described above. Further, nothing contained herein should be construed to create an employment contract. Occasionally, required skills/experiences for jobs are expressed in brief terms. Any language contained herein is intended to fully comply with all obligations imposed by the legislation of each country in which it operates, including the implementation of the EU Equality Directive, in relation to the recruitment and employment of its employees.
Summary Roles within the Clinical Trial Management job family are responsible for all aspects of the development, coordination, and implementation of Phase 1 clinical research studies at the organization's facilities. Collaborates with the principal investigator, liaisons between research subjects, client teams, investigators, and clinic operations teams, and plans logistics and resource usage. Tracks study progress in alignment with project milestones, client deliverables, and budget, and follows applicable regulations globally and by region. Impact and Contribution Includes executives as well as managers, supervisors and team leads providing strategic vision and/or tactical direction across a discipline and/or broader organization. The majority of time is spent overseeing their area of responsibility, planning, prioritizing, and/or directing the responsibilities of employees. Goal are achieved through management of process, policy, and performance of direct and/or indirect reports. Manages a team of individual contributors and/or Supervisors. Delivers operational results that have direct impact on immediate or short-term department results. In-depth knowledge and skills within a scientific/technology or professional discipline, understanding impact of work on related areas. Requires practical knowledge in managing the execution of processes, projects and tactics within team.
